
Discovery
of Osteoporosis Gene!
Decode
Genetics of Iceland says it has identified a gene linked
to osteoporosis. Its findings conclude that people with
any of three specific variants of gene have a threefold
risk of developing Osteoporosis, characterized by brittle
bones. The test for variant forms of the gene is being developed
by Roche Diagnostics and will be available in diagnostic
laboratories by next year. The genetic test needs to be
taken only once in a lifetime, and if the gene variant is
found, a high-calcium diet and plenty of exercise would
be prescribed.
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The gene
test may turn out to be more useful than a bone density test,
because it is more predictive. Although a density test shows
the state of a person’s current bone mineral loss –
which may or may not lead to fracture – a positive gene
test would indicate a definite risk.
Although the initial gene tests were done on Icelandic families
with at least one member who had both low bone-mineral density
and bone fractures, the tests have been confirmed in Denmark,
and are now being validated in the United States in a group
of women monitored for many years at the University of California
at San Francisco.
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